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Recombinant Human SIRT6 protein, T7/His-tagged

Cat.No. : SIRT6-213H
Product Overview : Recombinant human SIRT6 cDNA (355 aa, Isoform_1) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : T7/His
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEFSVNYAAGLSPYADKGKCGLPE IFDPPEELERKVWELARLVWQSSSV VFHTGAGISTASGIPDFRGPHGVWT MEERGLAPKFDTTFESARPTQTHMA LVQLERVGLLRFLVSQNVDGLHVRS GFPRDKLAELHGNMFVEECAKCKTQ YVRDTVVGTMGLKATGRLCTVAKAR GLRACRGELRDTILDWEDSLPDRDL ALADEASRNADLSITLGTSLQIRPS GNLPLATKRRGGRLVIVNLQPTKHD RHADLRIHGYVDEVMTRLMKHLGLE IPAWDGPRVLERALPPLPRPPTPKL EPKEESPTRINGSIPAGPKQEPCAQ HNGSEPASPKRERPTSPAPHRPPKR VKAKAVPS
Purity : >90% by SDS-PAGE.
Storage : Keep at -80°C for long term storage. Product is stable at 4 °C for at least 7 days.
Gene Name : SIRT6 sirtuin 6 [ Homo sapiens ]
Official Symbol : SIRT6
Synonyms : SIRT6; sirtuin 6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6;
Gene ID : 51548
mRNA Refseq : NM_001193285
Protein Refseq : NP_001180214
MIM : 606211
UniProt ID : Q8N6T7
Chromosome Location : 19p13.3
Pathway : Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function : NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); hydrolase activity; metal ion binding; protein binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is SIRT6 involved in DNA repair? 11/10/2021

SIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.

What is the nutritional significance of SIRT6? 08/30/2021

This proteinexpression of genes related to fat metabolism through deacetylation modifications.

Does SIRT6 have therapeutic potential? 09/25/2020

Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.

How does SIRT6 affect nutrient metabolism and energy balance? 05/19/2020

SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.

What is the effect of loss of SIRT6 on cells? 01/31/2020

Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.

How do the expression levels of SIRT6 differ in different tissues and cells? 01/01/2020

There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.

Customer Reviews (3)

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Reviews
07/21/2022

    This protein has high yield and good economic benefits.

    05/25/2022

      Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.

      12/13/2021

        SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

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