Recombinant Human SIRT6 protein, T7/His-tagged
Cat.No. : | SIRT6-213H |
Product Overview : | Recombinant human SIRT6 cDNA (355 aa, Isoform_1) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | T7/His |
Form : | 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
AA Sequence : | MASMTGGQQMGRGHHHHHHGNLYFQ GGEFSVNYAAGLSPYADKGKCGLPE IFDPPEELERKVWELARLVWQSSSV VFHTGAGISTASGIPDFRGPHGVWT MEERGLAPKFDTTFESARPTQTHMA LVQLERVGLLRFLVSQNVDGLHVRS GFPRDKLAELHGNMFVEECAKCKTQ YVRDTVVGTMGLKATGRLCTVAKAR GLRACRGELRDTILDWEDSLPDRDL ALADEASRNADLSITLGTSLQIRPS GNLPLATKRRGGRLVIVNLQPTKHD RHADLRIHGYVDEVMTRLMKHLGLE IPAWDGPRVLERALPPLPRPPTPKL EPKEESPTRINGSIPAGPKQEPCAQ HNGSEPASPKRERPTSPAPHRPPKR VKAKAVPS |
Purity : | >90% by SDS-PAGE. |
Storage : | Keep at -80°C for long term storage. Product is stable at 4 °C for at least 7 days. |
Gene Name : | SIRT6 sirtuin 6 [ Homo sapiens ] |
Official Symbol : | SIRT6 |
Synonyms : | SIRT6; sirtuin 6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; |
Gene ID : | 51548 |
mRNA Refseq : | NM_001193285 |
Protein Refseq : | NP_001180214 |
MIM : | 606211 |
UniProt ID : | Q8N6T7 |
Chromosome Location : | 19p13.3 |
Pathway : | Signaling events mediated by HDAC Class I, organism-specific biosystem; |
Function : | NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); hydrolase activity; metal ion binding; protein binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
SIRT6-28517H | Active Recombinant Human SIRT6 Protein, GST-tagged | +Inquiry |
SIRT6-2691H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-121H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-24H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
Sirt6-5885M | Recombinant Mouse Sirt6 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.
This proteinexpression of genes related to fat metabolism through deacetylation modifications.
Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.
SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.
Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.
There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.
Customer Reviews (3)
Write a reviewThis protein has high yield and good economic benefits.
Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.
SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
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