Recombinant Human SLC22A12 Protein, His-tagged

• Cat.No.: SLC22A12-399H
• Product Overview: Recombinant Human SLC22A12 Protein (Glu281-Thr350) with N-His tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 11.5 kDa
  Accurate Molecular Mass: 12 kDa
• Protein length: Glu281-Thr350
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: SLC22A12 solute carrier family 22 member 12 [ Homo sapiens (human) ]
• Official Symbol: SLC22A12
• Synonyms: SLC22A12; solute carrier family 22 member 12; RST; OAT4L; URAT1; solute carrier family 22 member 12; organic anion transporter 4-like protein; renal-specific transporter; solute carrier family 22 (organic anion/cation transporter), member 12; solute carrier family 22 (organic anion/urate transporter), member 12; urate anion exchanger 1; urate transporter 1
• Gene ID: 116085
• mRNA Refseq: NM_144585
• Protein Refseq: NP_653186
• MIM: 607096
• UniProt ID: Q96S37