Recombinant Human SMURF2 Protein (S2-E748), His tagged
Cat.No. : | SMURF2-0440H |
Product Overview : | Recombinant Human 6His-TEV-(GG)-SMURF2(S2-E748 end) Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein Length : | S2-E748 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ] |
Official Symbol : | SMURF2 |
Synonyms : | SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; E3 ubiquitin ligase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; MGC138150; DKFZp686F0270; |
Gene ID : | 64750 |
mRNA Refseq : | NM_022739 |
Protein Refseq : | NP_073576 |
MIM : | 605532 |
UniProt ID : | Q9HAU4 |
Products Types
◆ Recombinant Protein | ||
SMURF2-1714H | Recombinant Human SMURF2 Protein (1-748 aa), His-tagged | +Inquiry |
SMURF2-2050H | Recombinant Human SMURF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Smurf2-5985M | Recombinant Mouse Smurf2 Protein, Myc/DDK-tagged | +Inquiry |
SMURF2-8505M | Recombinant Mouse SMURF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMURF2-0441H | Recombinant Human SMURF2 Protein (S2-E748), Tag Free | +Inquiry |
◆ Lysates | ||
SMURF2-1646HCL | Recombinant Human SMURF2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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