| Description : |
This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
60 kDa |
| AA Sequence : |
MGTEGPPPPAASRGRQGCLLVPART KTTIALLYDEESENAYDIRLKLTKE VLTIQKQDVVCVGGSHQGRNRRTVT LRRQPVGGLGLSIKGGSEHNVPVVI SKIFEDQAADQTGMLFVGDAVLQVN GIHVENATHEEVVHLLRNAGDEVTI TVEYLREAPAFLKLPLGSPGPSSDH SSGASSPLFDSGLHLNGNSSTTAPS SPSSPIAKDPRYEKRWLDTLSVPLS MARISRYKAGTEKLRWNAFEVLALD GVSSGILRFYTAQDGTDWLRAVSAN IRELTLQNMKMANKCCSPSDQVVHM GWVNEKLQGADSSQTFRPKFLALKG PSFYVFSTPPVSTFDWVRAERTYHL CEVLFKVHKFWLTEDCWLQANLYLG LQDFDFEDQRPYCFSIVAGHGKSHV FNVELGSELAMWEKSFQRATFMEVQ RTGSRTYMCSWQGEMLCFTVDFALG FTCFESKTKNVLWRFKFSQLKGSSD DGKTRVKLLFQNLDTKQIETKELEF QDLRAVLHCIHSFIAAKVASVDPGF MDSQSLARKYMYSSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
