| Description : |
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
59 kDa |
| AA Sequence : |
MPLFATNPFDQDVEKATSEMNTAED WGLILDICDKVGQSRTGPKDCLRSI MRRVNHKDPHVAMQALTLLGACVSN CGKIFHLEVCSRDFASEVSNVLNKG HPKVCEKLKALMVEWTDEFKNDPQL SLISAMIKNLKEQGVTFPAIGSQAA EQAKASPALVAKDPGTVANKKEEED LAKAIELSLKEQRQQSTTLSTLYPS TSSLLTNHQHEGRKVRAIYDFEAAE DNELTFKAGEIITVLDDSDPNWWKG ETHQGIGLFPSNFVTADLTAEPEMI KTEKKTVQFSDDVQVETIEPEPEPA FIDEDKMDQLLQMLQSTDPSDDQPD LPELLHLEAMCHQMGPLIDEKLEDI DRKHSELSELNVKVMEALSLYTKLM NEDPMYSMYAKLQNQPYYMQSSGVS GSQVYAGPPPSGAYLVAGNAQMSHL QSYSLPPEQLSSLSQAVVPPSANPA LPSQQTQAAYPNTMVSSVQGNTYPS QAPVYSPPPAATAAAATADVTLYQN AGPNMPQVPNYNLTSSTLPQPGGSQ QPPQPQQPYSQKALLTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
