Recombinant Human STE20-like Kinase (Yeast), GST-tagged, Active

• Cat.No.: SLK-432H
• Product Overview: Recombinant full-length human SLK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 180 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex. Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity. CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.
• Sequence: Full length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SLK STE20-like kinase (yeast) [ Homo sapiens ]
• Synonyms: SLK; STE20-like kinase (yeast); LOSK; STK2; se20-9; KIAA0204; MGC133067; bA16H23.1; serine/threonine kinase 2; Long Ste20-like Kinase; CTCL tumor antigen se20-9; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; EC 2.7.11.1; OTTHUMP00000020426; OTTHUMP00000059183; Hslk; STE20-like kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; serine/threonine kinase 2
• Gene ID: 9748
• mRNA Refseq: NM_014720
• Protein Refseq: NP_055535
• UniProt ID: Q9H2G2
• Chromosome Location: 10q24.33
• Function: ATP binding; DNA binding; nuclease activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity