Recombinant Human SUCLA2 Protein, His-tagged SUCLA2-001H

Recombinant Human SUCLA2 Protein, His-tagged


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Recombinant Human SUCLA2 Protein, His-tagged

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Cat.No. : SUCLA2-001H
Product Overview : Recombinant Human SUCLA2 protein with a C-terminal His-tag was expressed in E.coli
Description : Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 29.8 kDa (α), 41.4 kDa (β)
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 nmol NADH per minute at 37 centigradein 34 mM Glycylglycine buffer, pH 8.4, 3.4 mM Magnesium Chloride, 1.2 mM ATP, 0.89 mM Coenzyme A, 5.8 mM Succinic acid, 4.1 U/mL pyruvate kinase, 3.4 U/mL Lactic Dehydrogenase.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 20% glycerol
Gene Name : SUCLA2 succinate-CoA ligase ADP-forming subunit beta [ Homo sapiens (human) ]
Official Symbol : SUCLA2
Synonyms : SUCLA2; succinate-CoA ligase ADP-forming subunit beta; A-SCS; A-BETA; MTDPS5; LINC00444; SCS-betaA; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase subunit beta; ATP-specific succinyl-CoA synthetase, beta subunit; long intergenic non-protein coding RNA 444; mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta; renal carcinoma antigen NY-REN-39; succinate-CoA ligase ADP-forming beta subunit; succinate-CoA ligase beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain; EC
Gene ID : 8803
mRNA Refseq : NM_003850
Protein Refseq : NP_003841
MIM : 603921
UniProt ID : P0A836

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