Recombinant Human SUCLA2 Protein, His-tagged

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Recombinant Human SUCLA2 Protein, His-tagged

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Cat.No. : SUCLA2-001H
Product Overview : Recombinant Human SUCLA2 protein with a C-terminal His-tag was expressed in E.coli
Description : Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 29.8 kDa (α), 41.4 kDa (β)
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 nmol NADH per minute at 37 centigradein 34 mM Glycylglycine buffer, pH 8.4, 3.4 mM Magnesium Chloride, 1.2 mM ATP, 0.89 mM Coenzyme A, 5.8 mM Succinic acid, 4.1 U/mL pyruvate kinase, 3.4 U/mL Lactic Dehydrogenase.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 20% glycerol
Gene Name : SUCLA2 succinate-CoA ligase ADP-forming subunit beta [ Homo sapiens (human) ]
Official Symbol : SUCLA2
Synonyms : SUCLA2; succinate-CoA ligase ADP-forming subunit beta; A-SCS; A-BETA; MTDPS5; LINC00444; SCS-betaA; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase subunit beta; ATP-specific succinyl-CoA synthetase, beta subunit; long intergenic non-protein coding RNA 444; mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta; renal carcinoma antigen NY-REN-39; succinate-CoA ligase ADP-forming beta subunit; succinate-CoA ligase beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain; EC 6.2.1.5
Gene ID : 8803
mRNA Refseq : NM_003850
Protein Refseq : NP_003841
MIM : 603921
UniProt ID : P0A836
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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