Recombinant Human SUN2 Protein, MYC/DDK-tagged

• Cat.No.: SUN2-3017H
• Product Overview: Recombinant Human SUN2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 80.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SUN2 Sad1 and UNC84 domain containing 2 [ Homo sapiens ]
• Official Symbol: SUN2
• Synonyms: UNC84B; UNC84B
• Gene ID: 25777
• mRNA Refseq: NM_001199579
• Protein Refseq: NP_001186508
• MIM: 613569
• UniProt ID: Q9UH99