Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K

• Cat.No.: SNCA-294H
• Product Overview: Recombinant Humanα-Synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques (140 aa, 14.4 kDa).

Specification

• Cat. No.: SNCA-294H
• Description: α-Synuclein E46K is a mutant form of α-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant (E46K) of α-synuclein causes Parkinson and Lewy Body dementia(DLB).
• Source: E.coli.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
• Molecular Weight: 14.4 kDa (Real molecular size on SDS-PAGE will be shift up).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by BCA assay).
• Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
• Storage: Store at -20 °C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: SNCA
• Synonyms: SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP).
• Gene ID: 6622
• mRNA Refseq: NM_000345.3
• Protein Refseq: NP_000336.1
• MIM: 163890
• UniProt ID: P37840
• Chromosome Location: 4q21
• Pathway: Alzheimer"s disease;Neurodegenerative Disorders; Parkinson"s disease.
• Function: Hsp70 protein binding;alpha-tubulin binding; dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity.