Recombinant Human TCEB2 protein

• Cat.No.: TCEB2-360H
• Product Overview: Recombinant Human TCEB2 protein is produced by E.coli expression system.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-118 aa
• Description: Elongin B , also known as TCEB2, is a subunit of the transcription factor B (SIII) complex. The SIII complex is a heterotrimer consisting of a transcriptionally active subunit (A) and two regulatory subunits (B and C). It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C, and thereby inhibits transcription elongation. Recombinant TCEB2 was expressed as insoluble protein aggregate in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 0.1 mM PMSF, 20% glycerol.
• Molecular Mass: 13.1 kDa
• AA Sequence: MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ
• Purity: > 95% by SDS - PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) [ Homo sapiens ]
• Official Symbol: TCEB2
• Synonyms: Elongin B; TCEB2; SIII p18; EloB; Elongin 18 kDa subunit; EloB; TCEB 2
• Gene ID: 6923
• mRNA Refseq: NM_007108
• Protein Refseq: NP_009039
• MIM: 600787
• UniProt ID: Q15370