Recombinant Human TFE3 Protein, His-tagged

• Cat.No.: TFE3-587H
• Product Overview: Recombinant Human TFE3 fused with His tag at N-terminal was expressed in Sf9 cells.

Specification

• Description: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
• Source: Sf9 cells
• Species: Human
• Tag: His
• Form: 50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 62 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TFE3 transcription factor binding to IGHM enhancer 3 [ Homo sapiens ]
• Official Symbol: TFE3
• Synonyms: TFE3; transcription factor binding to IGHM enhancer 3; transcription factor E3; bHLHe33; member A; TFEA; transcription factor E family; Transcription factor for IgH enhancer; transcription factor E family, member A; class E basic helix-loop-helix protein 33; RCCP2; RCCX1
• Gene ID: 7030
• mRNA Refseq: NM_006521
• Protein Refseq: NP_006512
• MIM: 314310
• UniProt ID: P19532