Recombinant Human THOC6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: THOC6-3175H
• Product Overview: THOC6 MS Standard C13 and N15-labeled recombinant protein (NP_077315) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 37.5 kDa
• AA Sequence: MERAVPLAVPLGQTEVFQALQRLHM TIFSQSVSPCGKFLAAGNNYGQIAI FSLSSALSSEAKEESKKPVVTFQAH DGPVYSMVSTDRHLLSAGDGEVKAW LWAEMLKKGCKELWRRQPPYRTSLE VPEINALLLVPKENSLILAGGDCQL HTMDLETGTFTRVLRGHTDYIHCLA LRERSPEVLSGGEDGAVRLWDLRTA KEVQTIEVYKHEECSRPHNGRWIGC LATDSDWMVCGGGPALTLWHLRSST PTTIFPIRAPQKHVTFYQDLILSAG QGRCVNQWQLSGELKAQVPGSSPGL LSLSLNQQPAAPECKVLTAAGNSCR VDVFTNLGYRAFSLSFTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: THOC6 THO complex 6 [ Homo sapiens (human) ]
• Official Symbol: THOC6
• Synonyms: THOC6; THO complex 6 homolog (Drosophila); WD repeat domain 58, WDR58; THO complex subunit 6 homolog; fSAP35; functional spliceosome associated protein 35; MGC2655; WD repeat domain 58; WD repeat-containing protein 58; functional spliceosome-associated protein 35; WDR58
• Gene ID: 79228
• mRNA Refseq: NM_024339
• Protein Refseq: NP_077315
• MIM: 615403
• UniProt ID: Q86W42