Recombinant Human Thrombomodulin

• Cat.No.: THBD-2601H
• Product Overview: Recombinant human thrombomodulin purified from aChinese Hamster Ovary (CHO)cell line, employing reverse phase, ion exchange chromatography and sizing columns.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: Thrombomodulin, CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells. In humans, thrombomodulin is encoded by the THBD gene. The protein has a molecular mass of 74kDa, and consists of a single chain with 5 distinct domains.
• Molecular Mass: 68 kDa.
• Presentation: Clear glass vial containing 10 μg of recombinant human thrombomodulin, lyophilized from a 100 μg/mL solution in 50 mM TRIS 0.1M NaCl pH 7.4, with 0.2M Mannitol added. Protein concentration determined using an extinction coefficient, ε1%, 280 nm = 0.88.
• Storage: Add 100 μL of filtered deionized water to the vial. Store lyophilized protein at 2-8°C. Reconstituted protein should be aliquoted in plastic tubes and stored frozen at –20°C. Avoid freeze thaw cycles.

Gene Information

• Gene Name: THBD thrombomodulin [ Homo sapiens ]
• Synonyms: THBD; thrombomodulin; TM; THRM; AHUS6; CD141; fetomodulin; CD141 antigen
• Gene ID: 7056
• mRNA Refseq: NM_000361
• Protein Refseq: NP_000352
• MIM: 188040
• UniProt ID: P07204
• Chromosome Location: 20p11.2
• Pathway: Complement and coagulation cascades; Hemostasis
• Function: calcium ion binding; protein binding; receptor activity; transmembrane receptor activity