Recombinant Human TIE1, Fc-His

• Cat.No.: TIE1-1686H
• Product Overview: Recombinant Human TIE1 encoding the extracellular domain was fused to the carboxy-terminal 6X his-tagged Fc region of human IgG1, inserted into a suitable mammalian expression vector and expressed inNSO cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc&His
• Description: Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo. They are expressed almost exclusively in endothelial cells. Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis. It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis.
• Molecular Weight: The predicted molecular weight of Recombinant Human Tie-1 is Mr 107 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 130-140 kDa.
• State Of Matter: Lyophilized.
• Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from a sterile solution containing 20 mM Tris, 0.5 M NaCl and 10% Sucrose.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Homo sapiens ]
• Synonyms: TIE1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; receptor tyrosine kinase; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; EC 2.7.10.1; JTK14; TIE; Tyrosine-protein kinase receptor Tie-1; OTTHUMP00000008352
• Gene ID: 7075
• mRNA Refseq: NM_005424
• Protein Refseq: NP_005415
• MIM: 600222
• UniProt ID: P35590
• Chromosome Location: 1p34-p33
• Function: ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity