| Description : |
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
125.1 kDa |
| AA Sequence : |
MVWRVPPFLLPILFLASHVGAAVDL TLLANLRLTDPQRFFLTCVSGEAGA GRGSDAWGPPLLLEKDDRIVRTPPG PPLRLARNGSHQVTLRGFSKPSDLV GVFSCVGGAGARRTRVIYVHNSPGA HLLPDKVTHTVNKGDTAVLSARVHK EKQTDVIWKSNGSYFYTLDWHEAQD GRFLLQLPNVQPPSSGIYSATYLEA SPLGSAFFRLIVRGCGAGRWGPGCT KECPGCLHGGVCHDHDGECVCPPGF TGTRCEQACREGRFGQSCQEQCPGI SGCRGLTFCLPDPYGCSCGSGWRGS QCQEACAPGHFGADCRLQCQCQNGG TCDRFSGCVCPSGWHGVHCEKSDRI PQILNMASELEFNLETMPRINCAAA GNPFPVRGSIELRKPDGTVLLSTKA IVEPEKTTAEFEVPRLVLADSGFWE CRVSTSGGQDSRRFKVNVKVPPVPL AAPRLLTKQSRQLVVSPLVSFSGDG PISTVRLHYRPQDSTMDWSTIVVDP SENVTLMNLRPKTGYSVRVQLSRPG EGGEGAWGPPTLMTTDCPEPLLQPW LEGWHVEGTDRLRVSWSLPLVPGPL VGDGFLLRLWDGTRGQERRENVSSP QARTALLTGLTPGTHYQLDVQLYHC TLLGPASPPAHVLLPPSGPPAPRHL HAQALSDSEIQLTWKHPEALPGPIS KYVVEVQVAGGAGDPLWIDVDRPEE TSTIIRGLNASTRYLFRMRASIQGL GDWSNTVEESTLGNGLQAEGPVQES RAAEEGLDQQLILAVVGSVSATCLT ILAALLTLVCIRRSCLHRRRTFTYQ SGSGEETILQFSSGTLTLTRRPKLQ PEPLSYPVLEWEDITFEDLIGEGNF GQVIRAMIKKDGLKMNAAIKMLKEY ASENDHRDFAGELEVLCKLGHHPNI INLLGACKNRGYLYIAIEYAPYGNL LDFLRKSRVLETDPAFAREHGTAST LSSRQLLRFASDAANGMQYLSEKQF IHRDLAARNVLVGENLASKIADFGL SRGEEVYVKKTMGRLPVRWMAIESL NYSVYTTKSDVWSFGVLLWEIVSLG GTPYCGMTCAELYEKLPQGYRMEQP RNCDDEVYELMRQCWRDRPYERPPF AQIALQLGRMLEARKAYVNMSLFEN FTYAGIDATAEEATRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
