| Description : |
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
138.7 kDa |
| AA Sequence : |
MDLHMMNCELLATCSALGYLEGDTY HKEPDCLESVKDLIRYLRHEDETRD VRQQLGAAQILQSDLLPILTQHHQD KPLFDAVIRLMVNLTQPALLCFGNL PKEPSFRHHFLQVLTYLQAYKEAFA SEKAFGVLSETLYELLQLGWEERQE EDNLLIERILLLVRNILHVPADLDQ EKKIDDDASAHDQLLWAIHLSGLDD LLLFLASSSAEEQWSLHVLEIVSLM FRDQNPEQLAGVGQGRLAQERSADF AELEVLRQREMAEKKTRALQRGNRH SRFGGSYIVQGLKSIGERDLIFHKG LHNLRNYSSDLGKQPKKVPKRRQAA RELSIQRRSALNVRLFLRDFCSEFL ENCYNRLMGSVKDHLLREKAQQHDE TYYMWALAFFMAFNRAASFRPGLVS ETLSVRTFHFIEQNLTNYYEMMLTD RKEAASWARRMHLALKAYQELLATV NEMDISPDEAVRESSRIIKNNIFYV MEYRELFLALFRKFDERCQPRSFLR DLVETTHLFLKMLERFCRSRGNLVV QNKQKKRRKKKKKVLDQAIVSGNVP SSPEEVEAVWPALAEQLQCCAQNSE LSMDSVVPFDAASEVPVEEQRAEAM VRIQDCLLAGQAPQALTLLRSAREV WPEGDVFGSQDISPEEEIQLLKQIL SAPLPRQQGPEERGAEEEEEEEEEE EEELQVVQVSEKEFNFLDYLKRFAC STVVRAYVLLLRSYQQNSAHTNHCI VKMLHRLAHDLKMEALLFQLSVFCL FNRLLSDPAAGAYKELVTFAKYILG KFFALAAVNQKAFVELLFWKNTAVV REMTEGYGSLDDRSSSRRAPTWSPE EEAHLRELYLANKDVEGQDVVEAIL AHLNTVPRTRKQIIHHLVQMGLADS VKDFQRKGTHIVLWTGDQELELQRL FEEFRDSDDVLGHIMKNITAKRSRA RIVDKLLALGLVAERRELYKKRQKK LASSILPNGAESLKDFCQEDLEEEE NLPEEDSEEEEEGGSEAEQVQGSLV LSNENLGQSLHQEGFSILLLWLQNC LIRAADDREEDGCSQAVPLVPLTEE NEEAMENEQFQQLLRKLGVRPPASG QETFWRIPAKLSPTQLRRAAASLSQ PEEEQKLQPELQPKVPGEQGSDEEH CKEHRAQALRALLLAHKKKAGLASP EEEDAVGKEPLKAAPKKRQLLDSDE EQEEDEGRNRAPELGAPGIQKKKRY QIEDDEDDTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
