Recombinant Human TMED10, His-tagged

• Cat.No.: TMED10-15897H
• Product Overview: Recombinant human TMED10 protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex"s gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer"s disease. This gene has a pseudogene on chromosome 8.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol.
• Molecular Mass: 20 kDa (177aa), confirmed by MALDI-TOF
• Protein length: 32-185aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TMED10 transmembrane emp24-like trafficking protein 10 (yeast) [ Homo sapiens ]
• Official Symbol: TMED10
• Synonyms: TMED10; transmembrane emp24-like trafficking protein 10 (yeast); transmembrane emp24 domain-containing protein 10; P24(DELTA); TMP21; p24delta; p24delta1; p24 family protein delta-1; transmembrane protein Tmp21; 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p23; S31I125; Tmp-21-I; S31III125
• Gene ID: 10972
• mRNA Refseq: NM_006827
• Protein Refseq: NP_006818
• MIM: 605406
• UniProt ID: P49755
• Chromosome Location: 14q24.3
• Pathway: mRNA processing, organism-specific biosystem
• Function: protein binding