Recombinant Human TNFRSF19, Fc Chimera TNFRSF19-2435H

Recombinant Human TNFRSF19, Fc Chimera


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Cat.No. : TNFRSF19-2435H Optional Service: Optional requirements on this protein
Product Overview : Recombinant cysteine-rich domain of human Troy (TAJ) (aa 1-168) produced inHEK 293 cellsis fused to the Fc portion of human IgG1. 48kDa (under reducing conditions).
Description : Troy, or TAJ, is a member of the tumor necrosis factor receptor (TNFR) family. Troy plays a role in axonal regeneration by forming a functional receptor complex with Nog-66 receptor 1 and LINGO-1. This receptor complex binds myelin inhibitors (Nogo-A, myelin.associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and signals myelin inhibition by activating RhoA. Troy also interacts with TRAF proteins and activates JNK.
Source/Host : HEK 293 cells.
Concentration : 1mg/ml after reconstitution.
Purity : ≥90% (SDS-PAGE).
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute in 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Formulation : Lyophilized. Contains PBS.
Long Term Storage : -20°C.
Use/Stability : Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C.
Handling : Avoid freeze/thaw cycles.
Gene Name : TNFRSF19 tumor necrosis factor receptor superfamily, member 19 [ Homo sapiens ]
Synonyms : tumor necrosis factor receptor superfamily, member 19; TAJ; TROY; TRADE; TAJ-alpha; TNFRSF19; tumor necrosis factor receptor superfamily member 19; toxicity and JNK inducer; Toxicity and JNK inducer; OTTHUMP00000018114
Gene ID : 55504
mRNA Refseq : NM_018647
Protein Refseq : NP_061117
MIM : 606122
UniProt ID : Q9NS68
Chromosome Location : 13q12.11-q12.3
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity; tumor necrosis factor receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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