Recombinant Human TNFRSF19, Fc Chimera
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Cat.No. : | TNFRSF19-2435H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant cysteine-rich domain of human Troy (TAJ) (aa 1-168) produced inHEK 293 cellsis fused to the Fc portion of human IgG1. 48kDa (under reducing conditions). |
Description : | Troy, or TAJ, is a member of the tumor necrosis factor receptor (TNFR) family. Troy plays a role in axonal regeneration by forming a functional receptor complex with Nog-66 receptor 1 and LINGO-1. This receptor complex binds myelin inhibitors (Nogo-A, myelin.associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and signals myelin inhibition by activating RhoA. Troy also interacts with TRAF proteins and activates JNK. |
Source/Host : | HEK 293 cells. |
Concentration : | 1mg/ml after reconstitution. |
Purity : | ≥90% (SDS-PAGE). |
Endotoxin Content : | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
Reconstitution : | Reconstitute in 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. |
Formulation : | Lyophilized. Contains PBS. |
Long Term Storage : | -20°C. |
Use/Stability : | Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C. |
Handling : | Avoid freeze/thaw cycles. |
Gene Name : | TNFRSF19 tumor necrosis factor receptor superfamily, member 19 [ Homo sapiens ] |
Synonyms : | tumor necrosis factor receptor superfamily, member 19; TAJ; TROY; TRADE; TAJ-alpha; TNFRSF19; tumor necrosis factor receptor superfamily member 19; toxicity and JNK inducer; Toxicity and JNK inducer; OTTHUMP00000018114 |
Gene ID : | 55504 |
mRNA Refseq : | NM_018647 |
Protein Refseq : | NP_061117 |
MIM : | 606122 |
UniProt ID : | Q9NS68 |
Chromosome Location : | 13q12.11-q12.3 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | protein binding; receptor activity; tumor necrosis factor receptor activity |
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◆ Lysates
TNFRSF19-2454MCL | Recombinant Mouse TNFRSF19 cell lysate | +Inquiry |
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TNFRSF10ATnfrsf10bTNFRSF10CTNFRSF10DTNFRSF11ATNFRSF11BTnfrsf12aTNFRSF13BTNFRSF13CTNFRSF14Tnfrsf17Tnfrsf18Tnfrsf19TNFRSF1ATNFRSF1BTNFRSF21Tnfrsf22Tnfrsf23TNFRSF25Tnfrsf26TNFRSF4TNFRSF6BTNFRSF8TNFRSF9TNFRSF12
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