Recombinant Human TNFSF9 Protein, FLAG-tagged

• Cat.No.: TNFSF9-157H
• Product Overview: Recombinant Human TNFSF9 Protein with a FLAG tag was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
• Endotoxin: Less than 1.0 EU/μg by the LAL method
• Purity: ＞85%, by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS, pH 7.4, 5% trehalose, 5% mannitol

Gene Information

• Gene Name: TNFSF9 TNF superfamily member 9 [ Homo sapiens (human) ]
• Official Symbol: TNFSF9
• Synonyms: TNFSF9 TNF superfamily member 9; CD137L; TNLG5A; 4-1BB-L; tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor superfamily member 9
• Gene ID: 8744
• mRNA Refseq: NM_003811
• Protein Refseq: NP_003802
• MIM: 606182
• UniProt ID: P41273