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Recombinant Human TPP1 protein, His-tagged

Cat.No. : TPP1-329H
Product Overview : Recombinant Human Tripeptidyl-Peptidase I is produced by our Mammalian expression system and the target gene encoding Ser20-Pro563 is expressed with a 6His tag at the C-terminus.
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Description : Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).
Source : HEK293
Species : Human
Tag : His
Form : Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5.
Molecular Mass : 23.94 kDa
Protein length : Ser20-Pro563
Endotoxin : Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Store at <-20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μl. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
Gene Name : TPP1
Official Symbol : TPP1
Synonyms : Tripeptidyl-Peptidase 1; TPP-1; Cell Growth-Inhibiting Gene 1 Protein; Lysosomal PepstatinInsensitive Protease; LPIC; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase I; TPP-I; TPP1; CLN2
Gene ID : 1200
mRNA Refseq : NM_000391.4
Protein Refseq : NP_000382.3
MIM : 607998
UniProt ID : O14773

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific inhibitors developed to target PKMYT1? 01/01/2023

Yes, several PKMYT1 inhibitors are under development and in preclinical and clinical trials for evaluating their efficacy in cancer treatment.

Are there ongoing clinical trials targeting PKMYT1? 09/03/2020

Yes, several clinical trials are investigating the efficacy of PKMYT1 inhibitors in various cancer types.

How does PKMYT1 influence cell cycle progression? 02/22/2019

PKMYT1 regulates the cell cycle by inhibiting the activity of cyclin-dependent kinases (CDKs), particularly CDK1, which is crucial for G2/M phase transition.

Can PKMYT1 be used as a predictive biomarker in cancer patients? 10/22/2017

Yes, the expression levels of PKMYT1 can be indicative of the responsiveness of cancer cells to specific treatments, making it a potential predictive biomarker.

How does PKMYT1 inhibition affect normal cell function? 07/30/2016

Selective PKMYT1 inhibitors aim to minimize effects on normal cells, but potential impacts on the cell cycle of non-cancerous cells are still under investigation.

Customer Reviews (3)

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Reviews
06/23/2019

    These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

    12/07/2018

      The manufacturer's support is crucial for researchers using TPP1 protein in trials.

      09/16/2018

        Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

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