Recombinant Human TRAF-Interacting Protein With Forkhead-Associated Domain, His-tagged

• Cat.No.: TIFA-5552H
• Product Overview: Recombinant humanTIFA protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: TIFA, also known asTRAF-interacting protein with FHA domain-containing protein A, is an adapterprotein which mediates the IRAK1 and TRAF6 interaction following IL-1stimulation, resulting in the downstream activation of NF-kappa-B and AP-1pathways. This protein induces the oligomerization and polyubiquitination ofTRAF6, which leads to the activation of TAK1 and IKK through aproteasome-independent mechanism.
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 20% glycerol 1mM DTT.
• Molecular Weight: 24.0 kDa (208aa)confirmed by MALDI-TOF.
• Purity: > 90% by SDS - PAGE.
• Concentration: 0.5 mg/ml(determined by Bradford assay).
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMTSFED ADTEETVTCL QMTVYHPGQL QCGIFQSISF NREKLPSSEV VKFGRNSNICHYTFQDKQVS RVQFSLQLFK KFNSSVLSFE IKNMSKKTNL IVDSRELGYL NKMDLPYRCM VRFGEYQFLMEKEDGESLEF FETQFILSPR SLLQENNWPP HRPIPEYGTY SLCSSQSSSP TEMDENES
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
• OfficialSymbol: TIFA
• Pathways: TNF-alpha/NF-kBSignaling Pathway

Gene Information

• Gene Name: TIFA TRAF-interacting proteinwith forkhead-associated domain [ Homo sapiens ]
• Synonyms: TIFA;TRAF-interacting protein with forkhead-associated domain; T2BP; T6BP; TIFAA;TRAF-interacting protein with FHA domain-containing protein A; TRAF2 bindingprotein; TRAF2-binding protein; TRAF6 binding protein; putativeMAPK-activating protein PM14; putative NF-kappa-B-activating protein 20; TRAF-interactingprotein with a forkhead-associated domain
• Gene ID: 92610
• mRNA Refseq: NM_052864
• Protein Refseq: NP_443096
• MIM: 609028
• UniProt ID: Q96CG3
• Chromosome Location: 4q25
• Function: protein binding