Recombinant Human TRIM38 Protein (A2-D465), Tag Free

• Cat.No.: TRIM38-0419H
• Product Overview: Recombinant Human (GG)-TRIM38(A2-D465 end) Protein was expressed in E. coli.

Specification

• Description: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters.
• Source: E. coli
• Species: Human
• Tag: No tag
• Form: Liquid
• Protein Length: A2-D465
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: TRIM38 tripartite motif containing 38 [ Homo sapiens (human) ]
• Official Symbol: TRIM38
• Synonyms: TRIM38; tripartite motif containing 38; ring finger protein 15, RNF15, tripartite motif containing 38; tripartite motif-containing protein 38; RORET; ring finger protein 15; zinc finger protein RoRet; zinc-finger protein RoRet; tripartite motif-containing 38; Ro/SSA ribonucleoprotein homolog; RNF15; MGC8946
• Gene ID: 10475
• mRNA Refseq: NM_006355
• Protein Refseq: NP_006346
• UniProt ID: O00635