"TTK" Related Products

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Recombinant Human TTK protein, MYC/DDK-tagged

Cat.No.: TTK-12H
Product Overview: Recombinant Human TTK fused with MYC/DDKtag at C-terminal was expressed in HEK293.
Description: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Source: HEK293
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 96.9 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: TTK TTK protein kinase [ Homo sapiens ]
Official Symbol: TTK
Synonyms: TTK; TTK protein kinase; dual specificity protein kinase TTK; cancer/testis antigen 96; CT96; MPS1L1; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; ESK; PYT; MPS1; FLJ38280;
Gene ID: 7272
mRNA Refseq: NM_003318
Protein Refseq: NP_003309
MIM: 604092
UniProt ID: P33981
Chromosome Location: 6q13-q21
Pathway: Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function: ATP binding; binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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