Recombinant Human TXK Tyrosine Kinase, GST-tagged, Active

• Cat.No.: TXK-453H
• Product Overview: Recombinant human TXK (239-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag.MW = 53 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 239-end a.a.
• Description: TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity.. Excessive TXK protein expression is seen in patients with Behcet"s disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet's disease.
• Sequence: 239-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: TXK TXK tyrosine kinase [ Homo sapiens ]
• Synonyms: TXK tyrosine kinase; RLK; TKL; BTKL; PTK4; PSCTK5; MGC22473; TXK; tyrosine kinase; PTK4 protein tyrosine kinase 4; EC 2.7.10.2
• Gene ID: 7294
• mRNA Refseq: NM_003328
• Protein Refseq: NP_003319
• MIM: 600058
• UniProt ID: P42681
• Chromosome Location: 4p12
• Pathway: Leukocyte transendothelial migration
• Function: non-membrane spanning protein tyrosine kinase activity; nucleotide binding; ATP binding; transferase activity; protein binding