"TYMS" Related Products

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Recombinant Human TYMS protein, His-tagged

Cat.No.: TYMS-685H
Product Overview: Recombinant Human TYMS fused with His tag at N-terminal was expressed in Insect cells.
Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Source: Insect cells
Species: Human
Tag: His
Form: 50mM Tris-HCl pH8.0, 150mM NaCl, 10% glycerol.
Molecular Mass: 36 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: TYMS thymidylate synthetase [ Homo sapiens ]
Official Symbol: TYMS
Synonyms: TYMS; thymidylate synthetase; TS; thymidylate synthase; HsT422; TMS; Tsase; TSase; HST422; MGC88736;
Gene ID: 7298
mRNA Refseq: NM_001071
Protein Refseq: NP_001062
MIM: 188350
UniProt ID: P04818
Chromosome Location: 18p11.31-p11.21
Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem;
Function: cofactor binding; folic acid binding; methyltransferase activity; nucleotide binding; thymidylate synthase activity; thymidylate synthase activity; transferase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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