| Description : |
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
43.1 kDa |
| AA Sequence : |
MSSPLASLSKTRKVPLPSEPMNPGR RGIRIYGDEDEVDMLSDGCGSEEKI SVPSCYGGIGAPVSRQGDSLAPPEV DFDRLLASLQDLSELVVEGDTQVTP VPGGARLRTLEPIPLKLYRNGIMMF DGPFQPFYDPSTQRCLRDILDGFFP SELQRLYPNGVPFKVSDLRNQVYLE DGLDPFPGEGRVVGRQLMHKALDRV EEHPGSRMTAEKFLNRLPKFVIRQG EVIDIRGPIRDTLQNCCPLPARIQE IVVETPTLAAERERSQESPNTPAPP LSMLRIKSENGEQAFLLMMQPDNTI GDVRALLAQARVMDASAFEIFSTFP PTLYQDDTLTLQAAGLVPKAALLLR ARRAPKSSLKFSPGPCPGPGPGPSP GPGPGPSPGPGPGPSPCPGPSPSPQ TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
