Recombinant Human UMPS Protein, His-tagged

• Cat.No.: UMPS-212H
• Product Overview: Recombinant Human UMPS(1-480aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Description: UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4).
• Molecular Mass: 53kDa (486aa) 50-70kDa (SDS-PAGE under reducing conditions)
• Protein length: 1-480aa
• AA Sequence: MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ
  IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML
  EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA
  DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP
  LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG
  RGIISAADRL EAAEMYRKAA WEAYLSRLGV HHHHHH
• Purity: > 95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: UMPS uridine monophosphate synthetase [ Homo sapiens ]
• Official Symbol: UMPS
• Synonyms: UMPS; uridine monophosphate synthetase; uridine 5-monophosphate synthase; orotate phosphoribosyl transferase and orotidine 5 decarboxylase; OPRTase; OMPdecase; UMP synthase; orotate phosphoribosyltransferase; orotidine 5-phosphate decarboxylase; OPRT
• Gene ID: 7372
• mRNA Refseq: NM_000373
• Protein Refseq: NP_000364
• MIM: 613891
• UniProt ID: P11172