Recombinant Human UNG protein

• Cat.No.: UNG-1547H
• Product Overview: Recombinant full length human UNG protein was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: This is the nuclear form of Uracil-DNA glycosylase (UNG). It is a DNA glycosylase without associated AP lyase activity (monofunctional glycosylase).
  Uracil in single-stranded and doublestranded DNA is the major substrate of this enzyme. The glycosylase is highly active in removing uracil residues from
  DNA by hydrolyzing the C-N glycosylic bond. Reaction products are free uracil and AP site in DNA. Uracil-DNA glycosylase is widely used for base excision repair studies and used for generating natural AP sites in DNA.
• Form: 50 mM Tris-HCl (pH7.5), 500 mM NaCl, and 10% glycerol.
• Molecular Mass: 40 kDa (35 UNG2 + ~5 kDa N-terminal tag)
• Storage: Stable for 2 years at -70 centigrade from date of shipment. Please aliquot to avoid repeated freezing and thawing.
• Full Length: Full L.
• Publications:
  Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming (2022)

Gene Information

• Gene Name: UNG uracil DNA glycosylase [ Homo sapiens (human) ]
• Official Symbol: UNG2
• Synonyms: DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; UNG; uracil DNA glycosylase
• Gene ID: 7374
• mRNA Refseq: NM_003362.3
• Protein Refseq: NP_003353.1
• MIM: 191525
• UniProt ID: P13051