Recombinant Human UPF1 Protein, MYC/DDK-tagged

• Cat.No.: UPF1-635H
• Product Overview: Recombinant human UPF1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 122.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: UPF1, RNA helicase and ATPase[ Homo sapiens ]
• Official Symbol: UPF1
• Synonyms: HUPF1; NORF1; pNORF1; RENT1; smg-2
• Gene ID: 5976
• mRNA Refseq: NM_002911.3
• Protein Refseq: NP_002902.2
• MIM: 601430
• UniProt ID: Q92900