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Recombinant Human USP9Y Protein (R1553-S1972), GST tagged

Cat.No. : USP9Y-0640H
Product Overview : Recombinant Human GST-TEV-GG-USP9Y(R1553-S1972) Protein was expressed in E. coli.
  • Specification
  • Gene Information
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Description : May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling.
Source : E. coli
Species : Human
Tag : GST
Form : Liquid
Protein Length : R1553-S1972
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name : USP9Y ubiquitin specific peptidase 9, Y-linked [ Homo sapiens (human) ]
Official Symbol : USP9Y
Synonyms : USP9Y; ubiquitin specific peptidase 9, Y-linked; ubiquitin specific peptidase 9, Y linked (fat facets like, Drosophila); probable ubiquitin carboxyl-terminal hydrolase FAF-Y; DFFRY; fat facets like homolog (Drosophila); ubiquitin thioesterase FAF-Y; deubiquitinating enzyme FAF-Y; ubiquitin thiolesterase FAF-Y; fat facets protein-related, Y-linked; ubiquitin-specific protease 9, Y chromosome; ubiquitin-specific processing protease FAF-Y; ubiquitin-specific-processing protease FAF-Y; ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila); SPGFY2; FLJ33043;
Gene ID : 8287
mRNA Refseq : NM_004654
Protein Refseq : NP_004645
MIM : 400005
UniProt ID : O00507

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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