Recombinant Human VAMP1, His-tagged

• Cat.No.: VAMP1-31695TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-91 of Human VAMP1 with an N terminal His tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-91 a.a.
• Description: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.
• Conjugation: HIS
• Tissue specificity: Nervous system, skeletal muscle and adipose tissue.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS, 1mM EDTA, pH 7.4
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W
• Sequence Similarities: Belongs to the synaptobrevin family.Contains 1 v-SNARE coiled-coil homology domain.

Gene Information

• Gene Name: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) [ Homo sapiens ]
• Official Symbol: VAMP1
• Synonyms: VAMP1; vesicle-associated membrane protein 1 (synaptobrevin 1); SYB1; vesicle-associated membrane protein 1; VAMP 1
• Gene ID: 6843
• mRNA Refseq: NM_014231
• Protein Refseq: NP_055046
• MIM: 185880
• Uniprot ID: P23763
• Chromosome Location: 12p
• Pathway: BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin, organism-specific biosystem; Botulinum neurotoxicity, organism-specific biosystem; Neuronal System, organism-specific biosystem; Proteolytic cleavage of SNARE complex proteins, organism-specific biosystem; SNARE interactions in vesicular transport, organism-specific biosystem
• Function: protein binding