Recombinant Human VPS72 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: VPS72-5247H
• Product Overview: VPS72 MS Standard C13 and N15-labeled recombinant protein (NP_005988) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
• Molecular Mass: 40.6 kDa
• AA Sequence: MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIKTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: VPS72 vacuolar protein sorting 72 homolog [ Homo sapiens (human) ]
• Official Symbol: VPS72
• Synonyms: VPS72; vacuolar protein sorting 72 homolog (S. cerevisiae); TCFL1, transcription factor like 1, vacuolar protein sorting 72 (yeast); vacuolar protein sorting-associated protein 72 homolog; Swc2; YL 1; YL1; protein YL-1; transcription factor-like 1 (YL-1); CFL1; YL-1; TCFL1
• Gene ID: 6944
• mRNA Refseq: NM_005997
• Protein Refseq: NP_005988
• MIM: 600607
• UniProt ID: Q15906