| Description : |
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
59.3 kDa |
| AA Sequence : |
MKTLETQPLAPDCCPSDQDPAPAHP SPHASPMNKNADSELMPPPPERGDP PRLSPDPVAGSAVSQELREGDPVSL STPLETEFGSPSELSPRIEEQELSE NTSLPAEEANGSLSEEEANGPELGS GKAMEDTSGEPAAEDEGDTAWNYSF SQLPRFLSGSWSEFSTQPENFLKGC KWAPDGSCILTNSADNILRIYNLPP ELYHEGEQVEYAEMVPVLRMVEGDT IYDYCWYSLMSSAQPDTSYVASSSR ENPIHIWDAFTGELRASFRAYNHLD ELTAAHSLCFSPDGSQLFCGFNRTV RVFSTARPGRDCEVRATFAKKQGQS GIISCIAFSPAQPLYACGSYGRSLG LYAWDDGSPLALLGGHQGGITHLCF HPDGNRFFSGARKDAELLCWDLRQS GYPLWSLGREVTTNQRIYFDLDPTG QFLVSGSTSGAVSVWDTDGPGNDGK PEPVLSFLPQKDCTNGVSLHPSLPL LATASGQRVFPEPTESGDEGEELGL PLLSTRHVHLECRLQLWWCGGAPDS SIPDDHQGEKGQGGTEGGVGELITR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
