Recombinant Human YTH N6-methyladenosine RNA binding protein C2 Protein, His tagged

• Cat.No.: YTHDC2-012H
• Product Overview: Recombinant human YTHDC2 protein (Q9H6S0) (Met 1286-Asp 1430) with a His tag at the C-terminus was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1286-1430aa
• Description: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
• Tag: C-His
• Molecular Mass: 18.4 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: YTHDC2 YTH N6-methyladenosine RNA binding protein C2 [ Homo sapiens (human) ]
• Official Symbol: YTHDC2
• Synonyms: YTHDC2; YTH N6-methyladenosine RNA binding protein C2; CAHL; hYTHDC2; 3'-5' RNA helicase YTHDC2; CsA-associated helicase-like protein; YTH domain containing 2; probable ATP-dependent RNA helicase YTHDC2; EC 3.6.4.13
• Gene ID: 64848
• mRNA Refseq: NM_022828.3
• Protein Refseq: NP_073739.3
• MIM: 616530
• UniProt ID: Q9H6S0