Recombinant Human ZRANB1 Protein (M1-E708), His tagged

• Cat.No.: ZRANB1-1332S
• Product Overview: Recombinant Human ZRANB1(M1-E708 end)-TEV-8His Protein was expressed in Insect cell.

Specification

• Description: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: M1-E708
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ZRANB1 zinc finger, RAN-binding domain containing 1 [ Homo sapiens (human) ]
• Official Symbol: ZRANB1
• Synonyms: ZRANB1; zinc finger, RAN-binding domain containing 1; ubiquitin thioesterase ZRANB1; TRABID; hTrabid; TRAF-binding protein domain; TRAF-binding domain-containing protein; zinc finger Ran-binding domain-containing protein 1; DKFZp762P2216
• Gene ID: 54764
• mRNA Refseq: NM_017580
• Protein Refseq: NP_060050
• MIM: 611749
• UniProt ID: Q9UGI0