Recombinant MERS-CoV(EMC 2C/2012) S(RBD) protein

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Recombinant MERS-CoV(EMC 2C/2012) S(RBD) protein

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Cat.No. : MERSS-108V
Product Overview : Purified recombinant MERS-CoV(EMC 2C/2012) S(RBD) protein was expressed in HEK293 cells.
Description : Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Source : HEK293
Species : MERS-CoV
Form : Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4).
Purity : >95%
Applications : WB standard, Ab ELISA, immunogen, etc.
Usage : For research use only, not for use in diagnostic procedures.
Storage : Store at -80 centigrade, Avoid freeze/thaw cycle.
Concentration : 1 mg/ml
Gene Name : S
Official Symbol : S
Synonyms : G128_gp02
Gene ID : 14254594
Protein Refseq : YP_009047204.1
UniProt ID : W6A028

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