Recombinant MERS-CoV(EMC 2C/2012) S(ΔTM) protein

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Recombinant MERS-CoV(EMC 2C/2012) S(ΔTM) protein

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Cat.No. : MERSS-106V
Product Overview : Purified recombinant MERS-CoV(EMC 2C/2012) S(ΔTM) protein was expressed in HEK293 cells.
Description : Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Source : HEK293
Species : MERS-CoV
Form : Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4).
Purity : >95%
Applications : WB standard, Ab ELISA, immunogen, etc.
Usage : For research use only, not for use in diagnostic procedures.
Storage : Store at -80 centigrade, Avoid freeze/thaw cycle.
Concentration : 1 mg/ml
Gene Name : S
Official Symbol : S
Synonyms : G128_gp02
Gene ID : 14254594
Protein Refseq : YP_009047204.1
UniProt ID : W6A028
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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