Recombinant Mouse Ackr1 Protein, Myc/DDK-tagged

• Cat.No.: Ackr1-1495M
• Product Overview: Purified recombinant protein of mouse full-length atypical chemokine receptor 1 (Duffy blood group) (Ackr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 36.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ackr1 atypical chemokine receptor 1 (Duffy blood group) [ Mus musculus (house mouse) ]
• Official Symbol: Ackr1
• Synonyms: Ackr1; atypical chemokine receptor 1 (Duffy blood group); Da; FY; Dfy; GPD; CCBP; Darc; CCBP1; CD234; ESTM3; ESTM35; AA162249; atypical chemokine receptor 1; Duffy antigen receptor for chemokines; Duffy blood group, chemokine receptor; duffy antigen/chemokine receptor; glycoprotein D
• Gene ID: 13349
• mRNA Refseq: NM_010045
• Protein Refseq: NP_034175
• UniProt ID: Q9QUI6