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Recombinant Mouse AKAP3 Protein

Cat.No. : AKAP3-1477M
Product Overview : Recombinant Mouse AKAP3 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Akap3 A kinase (PRKA) anchor protein 3 [ Mus musculus ]
Official Symbol : AKAP3
Gene ID : 11642
mRNA Refseq : NM_009650.2
Protein Refseq : NP_033780.2
MIM :
UniProt ID : O88987

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (23)

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Do mutations or genetic variants in the AKAP3 gene cause any diseases? 05/20/2023

To date, no disease-causing mutations or genetic variants in the AKAP3 gene have been identified. However, given its importance in sperm motility and fertility, it is possible that genetic abnormalities in AKAP3 could contribute to male infertility or other reproductive disorders. Further research is needed to explore potential disease associations.

Can AKAP3 be used as a biomarker for male fertility or reproductive disorders? 03/12/2023

At present, there is limited evidence suggesting that AKAP3 could serve as a biomarker for male fertility or reproductive disorders. However, ongoing research is exploring the potential use of protein biomarkers in evaluating sperm quality and male fertility. As our understanding of AKAP3's role in sperm function and male fertility improves, it is possible that it could be considered as a biomarker in the future, along with other molecular markers, to assess male fertility status and reproductive disorders.

Can AKAP3 be used as a biomarker for male infertility or reproductive disorders? 05/16/2022

While AKAP3 is involved in sperm motility and male fertility, it is not currently used as a biomarker for male infertility or reproductive disorders. However, given its importance in these processes, continued research may uncover the potential for AKAP3 to serve as a biomarker for certain conditions. Currently, diagnostic methods for male infertility primarily focus on assessing sperm parameters such as count, motility, and morphology.

Can changes in AKAP3 expression or activity impact male fertility? 04/07/2022

Yes, changes in AKAP3 expression or activity can impact male fertility. AKAP3 is crucial for the assembly and organization of the fibrous sheath in sperm cells, which is necessary for sperm movement. Any disruptions in AKAP3 function could lead to abnormalities in the fibrous sheath, resulting in impaired sperm motility and reduced fertility. Studies have suggested that alterations in AKAP3 expression or mutations in the AKAP3 gene could be associated with male infertility.

Are there any drugs or interventions that can target AKAP3 for therapeutic purposes? 12/13/2021

Currently, there are no specific drugs or interventions targeting AKAP3 for therapeutic purposes. However, given its importance in sperm motility and male fertility, further research to identify potential therapeutic targets within the AKAP3 signaling pathway is underway. Modulating AKAP3 activity or its interacting partners might hold potential in the development of future treatments for male infertility or reproductive disorders. However, it is important to note that more research is needed in this area before any specific interventions can be developed.

Can AKAP3 be targeted for contraceptive purposes? 12/14/2020

Although AKAP3 plays a crucial role in sperm motility and fertility, there is currently limited research on directly targeting AKAP3 for contraceptive purposes. However, the potential for AKAP3 modulation to affect sperm function suggests that further exploration in this area may be warranted. Any potential development of AKAP3-based contraceptives would require extensive research and development to ensure safety, efficacy, and reversibility.

Are there any known inhibitors of AKAP3 activity or downstream signaling pathways? 04/24/2020

Currently, there are no known specific inhibitors of AKAP3 activity or downstream signaling pathways. However, research is continuously being conducted to identify compounds or therapeutic targets that may modulate the function or activity of AKAP3. By understanding the specific interactions and mechanisms involved in the AKAP3 signaling pathway, it may be possible to identify potential inhibitors in the future for therapeutic purposes.

What are the potential implications of targeting AKAP3 for male contraceptive development? 10/21/2019

Targeting AKAP3 for male contraceptive development could have significant implications for reproductive health. Since AKAP3 is involved in sperm motility, any disruption or inhibition of its function could potentially lead to decreased or impaired sperm movement, potentially leading to temporary or reversible infertility. However, it is important to note that the development of male contraceptives targeting AKAP3 would require careful consideration of potential side effects and long-term implications.

Can changes in AKAP3 expression or activity affect the fertilization process? 09/24/2019

Yes, changes in AKAP3 expression or activity can potentially affect the fertilization process. AKAP3 is involved in sperm motility, which is crucial for sperm cells to reach and penetrate the oocyte (egg) during fertilization. If there are abnormalities in the fibrous sheath assembly or organization due to altered AKAP3 function, it could impair sperm movement and hinder successful fertilization. However, more research is needed to fully understand the precise role of AKAP3 in the fertilization process and how changes in its expression or activity could impact fertility.

Is AKAP3 involved in any other cellular processes besides sperm motility? 11/11/2018

While AKAP3 is primarily known for its role in sperm motility, there is evidence to suggest its involvement in other cellular processes as well. It has been shown to interact with other signaling molecules, such as adenylate cyclase and phosphodiesterase, indicating its potential role in modulating cyclic AMP (cAMP) signaling pathways. Altered cAMP signaling has been implicated in various cellular processes, including cell growth, differentiation, and survival. However, more research is needed to fully understand the broader functions of AKAP3 beyond sperm motility.

Are there any animal models or studies investigating AKAP3 function in fertility? 07/05/2018

Yes, several animal models and studies have been conducted to investigate AKAP3 function in fertility. Animal models such as mice, rats, and rabbits have been used to study the role of AKAP3 in sperm development, motility, and fertility. These studies provide valuable insights into the molecular mechanisms and physiological functions of AKAP3 in reproductive processes, which can help inform further research on human fertility and potential therapeutic interventions.

Can AKAP3 mutations or dysregulation lead to any other health conditions or diseases? 10/10/2017

Currently, there is limited research on whether AKAP3 mutations or dysregulation can lead to other health conditions or diseases beyond male infertility. However, studies have suggested a potential link between AKAP3 polymorphisms and an increased risk of testicular cancer. Further research is necessary to understand the potential implications of AKAP3 mutations or dysregulation on other health conditions or diseases.

Are there any known genetic mutations or polymorphisms in the AKAP3 gene associated with male fertility problems? 09/18/2017

There have been reports of genetic mutations and polymorphisms in the AKAP3 gene associated with male fertility problems. A study identified a genetic mutation in the AKAP3 gene in a family with multiple cases of infertility. Another study found a genetic polymorphism in the AKAP3 gene that was associated with reduced sperm motility and increased risk of male infertility. These findings suggest that genetic variations in the AKAP3 gene could contribute to male fertility issues, but further research is necessary to confirm and fully understand their impact.

Is AKAP3 expression limited to sperm cells, or is it expressed in other tissues as well? 08/17/2017

AKAP3 is primarily expressed in the testes, specifically in developing sperm cells. It plays a crucial role in spermatogenesis and sperm motility. While AKAP3 expression is predominantly found in sperm cells, there is some evidence suggesting that it may be expressed in low levels in other tissues as well, such as the heart, lungs, and brain. However, its functional significance in these tissues is not well understood, and more research is needed to fully characterize AKAP3 expression beyond the testes.

Is AKAP3 found in other tissues or organs besides the testes? 06/21/2017

AKAP3 is predominantly expressed in the testes, specifically in the sperm cells. Its expression is limited to the male reproductive system and is primarily associated with spermatogenesis and sperm function. Its expression in other tissues or organs is negligible or absent.

How does AKAP3 interact with other proteins involved in sperm motility? 05/24/2017

AKAP3 interacts with various proteins involved in sperm motility to regulate and coordinate their functions. It interacts with structural proteins like AKAP4 and AKAP82 in the fibrous sheath of the sperm tail, which plays a crucial role in generating the whip-like movement. AKAP3 also interacts with enzymes like protein kinase A (PKA) and protein kinase C (PKC), which are involved in signal transduction pathways regulating sperm motility. These interactions help facilitate the proper assembly and organization of the sperm tail and the regulation of intracellular signaling pathways involved in motility.

Is AKAP3 involved in any other cellular processes besides sperm motility? 01/17/2017

While AKAP3's primary function is associated with sperm motility, it is also involved in other cellular processes. For example, AKAP3 has been found to interact with other proteins involved in DNA repair, suggesting a potential role in maintaining genomic stability. Additionally, AKAP3 has been implicated in the regulation of protein localization within cells, specifically in the context of the fibrous sheath structure in sperm tails. Further research is needed to fully elucidate the extent of AKAP3's involvement in other cellular processes.

Are there any clinical trials testing AKAP3-related therapies for male infertility? 11/18/2016

As of now, there are no clinical trials specifically testing AKAP3-related therapies for male infertility. However, ongoing research in the field of male contraception and reproductive health may lead to future clinical trials evaluating the efficacy and safety of potential AKAP3-targeted therapies. Clinical trials often take time to conduct and require a rigorous evaluation process to ensure patient safety and therapeutic efficacy.

Can AKAP3 interact with other AKAPs or signaling molecules? 09/09/2016

AKAP3 can interact with other AKAPs and signaling molecules to form multiprotein complexes involved in sperm function. It has been shown to interact with PKA, as well as other fibrous sheath-associated proteins, such as AKAP4 and AKAP82. These interactions are crucial for the proper assembly and organization of the fibrous sheath and the regulation of sperm motility.

Are there any known factors or environmental influences that can regulate AKAP3 expression or activity? 06/15/2016

There is limited research on factors or environmental influences that can directly regulate AKAP3 expression or activity. However, studies have suggested that hormonal factors, such as FSH and testosterone, can influence AKAP3 expression. Additionally, environmental factors, such as exposure to toxins or chemicals, may indirectly affect AKAP3 expression by disrupting the overall testicular environment or impairing spermatogenesis. Further research is needed to identify specific factors and provide a comprehensive understanding of the regulation of AKAP3 expression and activity.

Are there any therapeutic implications or potential interventions targeting AKAP3? 03/14/2016

Currently, there are no specific therapeutic interventions targeting AKAP3. However, understanding its role in sperm motility and fertility could have implications for the development of potential treatments for male infertility or reproductive disorders. Further research is needed to explore the therapeutic potential of targeting AKAP3 or related signaling pathways.

Are there any known regulatory mechanisms that control AKAP3 expression? 12/07/2015

The regulation of AKAP3 expression is not fully understood, but studies have identified some potential regulatory mechanisms. It has been reported that AKAP3 expression is under the control of testicular-specific transcription factors, such as CREB (cAMP response element-binding) and SOX9 (SRY-related HMG box 9). Additionally, hormonal factors, such as follicle-stimulating hormone (FSH) and testosterone, have been shown to influence AKAP3 expression. Further research is needed to elucidate the complete regulatory network governing AKAP3 expression.

Are there any genetic tests available to identify AKAP3 mutations or dysregulation? 04/21/2015

Currently, there are no specific genetic tests available to identify AKAP3 mutations or dysregulation. Due to limited research and understanding of AKAP3's role in male infertility, diagnostic genetic testing is not routinely performed for AKAP3 gene variants. However, as research advances, it is possible that specialized genetic tests may become available in the future to identify specific AKAP3 mutations or dysregulation.

Customer Reviews (4)

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Reviews
03/15/2022

    The AKAP3 protein exudes excellence, boasting exceptional quality that surpasses my experimental requirements.

    12/13/2021

      the manufacturer of the AKAP3 protein offers unparalleled technical support that can effectively address any challenges I may encounter.

      05/20/2019

        Utilizing the AKAP3 protein in my experiments instills a sense of assurance, as it promises to be a powerful tool in advancing my scientific investigations.

        06/30/2018

          With its outstanding purity and functionality, this protein is poised to seamlessly align with the objectives of my research, delivering accurate and reliable results.

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