Recombinant Mouse Arhgap17 Protein, Myc/DDK-tagged

• Cat.No.: Arhgap17-1680M
• Product Overview: Purified recombinant protein of mouse full-length Rho GTPase activating protein 17 (Arhgap17), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 79.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Arhgap17 Rho GTPase activating protein 17 [ Mus musculus (house mouse) ]
• Official Symbol: Arhgap17
• Synonyms: Arhgap17; Rho GTPase activating protein 17; N; Na; Ric; WBP1; Rich1; Wbp15; Nadrin; Nadrin2; 5730403H17Rik; rho GTPase-activating protein 17; WW domain-binding protein 15; neuron-associated developmentally regulated protein; rho-type GTPase-activating protein 17
• Gene ID: 70497
• mRNA Refseq: NM_001122643
• Protein Refseq: NP_001116115
• UniProt ID: Q3UIA2