Recombinant Mouse Camk1 Protein, Myc/DDK-tagged
Cat.No. : | Camk1-1943M |
Product Overview : | Purified recombinant protein of mouse full-length calcium/calmodulin-dependent protein kinase I (Camk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x2-[ST]-x3-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-673', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 41.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Camk1 calcium/calmodulin-dependent protein kinase I [ Mus musculus (house mouse) ] |
Official Symbol : | Camk1 |
Synonyms : | CAMK1; calcium/calmodulin-dependent protein kinase I; calcium/calmodulin-dependent protein kinase type 1; caM-KI; caMKI-alpha; caM kinase I alpha; AI505105; CaMKIalpha; D6Ertd263e |
Gene ID : | 52163 |
mRNA Refseq : | NM_133926 |
Protein Refseq : | NP_598687 |
UniProt ID : | Q91YS8 |
Products Types
◆ Recombinant Protein | ||
CAMK1-5372H | Recombinant Human Calcium/Calmodulin-Dependent Protein Kinase I, His-tagged | +Inquiry |
CAMK1-0317H | Active Recombinant Human CAMK1 Protein, GST-Tagged | +Inquiry |
CAMK1-763R | Recombinant Rat CAMK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CAMK1-0320H | Recombinant Human CAMK1 Protein, GST-Tagged | +Inquiry |
CAMK1-489H | Recombinant Human CAMK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CAMK1-7883HCL | Recombinant Human CAMK1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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