Recombinant Mouse Cardiotrophin 2
Cat.No. : | Ctf2-952M |
Product Overview : | Recombinant mouse Neuropoietin produced inE.Coliis a 19.8 kDa protein containing 183 amino acid residues. |
- Specification
- Gene Information
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Cat. No. : | Ctf2-952M |
Description : | Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. |
Source : | E.Coli. |
Purity : | > 98% by SDS-PAGE. |
Endotoxin Level : | < 0.1 ng per μg of Neuropoietin. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biological Activity : | The ED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 μg/ml. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Neuropoietin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles. |
Gene Name : | Ctf2 cardiotrophin 2 [ Mus musculus ] |
Synonyms : | cardiotrophin 2; NP; Gm494; Ctf2; neuropoietin; LOC244218 |
Gene ID : | 244218 |
mRNA Refseq : | NM_198858 |
Protein Refseq : | NP_942155 |
UniProt ID : | P83714 |
Chromosome Location : | 7 F3 |
Function : | ciliary neurotrophic factor receptor binding; leukemia inhibitory factor receptor binding; cytokine activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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