| Description : |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. |
| Source : |
E.coli cell free |
| Species : |
Mouse |
| Tag : |
His/SUMO |
| Form : |
Tris-based buffer,50% glycerol |
| Protein length : |
1-264 aa |
| AA Sequence : |
MATTTCQVVGLLLSLLGLAGCIAAT GMDMWSTQDLYDNPVTAVFQYEGLW RSCVQQSSGF TECRPYFTILGLPAMLQAVRALMIV GIVLGVIGILVSIFALKCIRIGSMD DSAKAKMTLT SGILFIISGICAIIGVSVFANMLVT NFWMSTANMYSGMGGMGGMVQTVQT RYTFGAALFV GWVAGGLTLIGGVMMCIACRGLTPD DSNFKAVSYHASGQNVAYRPGGFKA STGFGSNTRN KKIYDGGARTEDDEQSHPTKYDYV |
| Notes : |
Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigradefor up to one week. |
| Storage : |
Store at -20 centigrade, for extended storage, conserve at -20 centigradeor -80 centigrade. |
