Recombinant Mouse Cmtm6 Protein, Myc/DDK-tagged

• Cat.No.: Cmtm6-2212M
• Product Overview: Purified recombinant protein of mouse full-length CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 19.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 [ Mus musculus (house mouse) ]
• Official Symbol: Cmtm6
• Synonyms: CMTM6; CKLF-like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain-containing protein 6; chemokine-like factor superfamily 6; chemokine-like factor super family 6; chemokine-like factor superfamily member 6; Cklfsf6; AA536733; 2810051A14Rik
• Gene ID: 67213
• mRNA Refseq: NM_026036
• Protein Refseq: NP_080312
• UniProt ID: Q9CZ69