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Recombinant Mouse Cops7a Protein, Myc/DDK-tagged

Cat.No. : Cops7a-2265M
Product Overview : Purified recombinant protein of mouse full-length COP9 signalosome subunit 7A (Cops7a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 30.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cops7a COP9 signalosome subunit 7A [ Mus musculus (house mouse) ]
Official Symbol : Cops7a
Synonyms : Cops7a; COP9 signalosome subunit 7A; SGN7a; D6Ertd35; D6Ertd35e; COP9 signalosome complex subunit 7a; COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; JAB1-containing signalosome subunit 7a; signalosome subunit 7a
Gene ID : 26894
mRNA Refseq : NM_012003
Protein Refseq : NP_036133
UniProt ID : Q9CZ04

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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