| Description : |
This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
52 kDa |
| Protein Length : |
476 |
| AA Sequence : |
MAGRGGRVLLALCAALVAGGWLLTA EAQEPGAPAAGMRRRRRLQQEDGIS FEYHRYPELREALVSVWLQCTAISR IYTVGRSFEGRELLVIELSDNPGVH EPGEPEFKYIGNMHGNEAVGRELLI FLAQYLCNEYQKGNETIVNLIHSTR IHIMPSLNPDGFEKAASQPGELKDW FVGRSNAQGIDLNRNFPDLDRIVYV NEKEGGPNNHLLKNLKKIVDQNSKL APETKAVIHWIMDIPFVLSANLHGG DLVANYPYDETRSGTAHEYSSCPDD AIFQSLARAYSSFNPVMSDPNRPPC RKNDDDSSFVDGTTNGGAWYSVPGG MQDFNYLSSNCFEITVELSCEKFPP EETLKSYWEDNKNSLISYLEQIHRG VKGFVRDLQGNPIANATISVDGIDH DVTSAKDGDYWRLLAPGNYKLTASA PGYLAITKKVAVPFSPAVGVDFELE SFSERKEEEKEELMEWWKMMSETLN F |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
