Recombinant Mouse Ctdspl Protein, Myc/DDK-tagged

• Cat.No.: Ctdspl-2355M
• Product Overview: Purified recombinant protein of mouse full-length CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (Ctdspl), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
• Molecular Mass: 31.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like [ Mus musculus (house mouse) ]
• Official Symbol: Ctdspl
• Synonyms: CTDSPL; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein; CTDSP-like; NIF-like protein; small CTD phosphatase 3; NLI-interacting factor 1; small C-terminal domain phosphatase 3; nuclear LIM interactor-interacting factor 1; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; SCP3; HYA22; AI426263; 2810418J22Rik
• Gene ID: 69274
• mRNA Refseq: NM_133710
• Protein Refseq: NP_598471
• UniProt ID: P58465