Recombinant Mouse Dhh protein
Cat.No. : | Dhh-393M |
Product Overview : | Recombinant Mouse Dhh protein was expressed in Escherichia coli. |
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Description : | This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. |
Source : | E.coli |
Species : | Mouse |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4, 1 mM DTT, 0.05 % Tween-80. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by murine MC3T3-E1 cells is 5-20 μg/ml. |
Molecular Mass : | Approximately 20.0 kDa, a single non-glycosylated polypeptide chain containing 177 amino acids. |
Protein length : | 177 |
AA Sequence : | IIGPGRGPVGRRRYVRKQLVPLLYK QFVPSMPERTLGASGPAEGRVTRGS ERFRDLVPNYNPDIIFKDEENSGAD RLMTERCKERVNALAIAVMNMWPGV RLRVTEGWDEDGHHAQDSLHYEGRA LDITTSDRDRNKYGLLARLAVEAGF DWVYYESRNHIHVSVKADNSLAVRA GG |
Endotoxin : | Less than 0.1 EU/μg of rMuDHH C23II as determined by LAL method. |
Purity : | >98% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Tag : | Non |
Gene Name : | Dhh |
Official Symbol : | Dhh |
Synonyms : | DHH; desert hedgehog; desert hedgehog protein; HHG-3; C78960; MGC73610; |
Gene ID : | 13363 |
mRNA Refseq : | NM_007857 |
Protein Refseq : | NP_031883 |
UniProt ID : | Q61488 |
Products Types
◆ Recombinant Protein | ||
DHH-432D | Active Recombinant Human DHH Protein (177 aa) | +Inquiry |
DHH-1337H | Recombinant Human DHH Protein, His-tagged | +Inquiry |
DHH-332H | Recombinant Human DHH protein, His-GST&Myc-tagged | +Inquiry |
Dhh-431D | Active Recombinant Mouse Dhh Protein (176 aa) | +Inquiry |
DHH-2589H | Recombinant Human DHH Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
DHH-469HCL | Recombinant Human DHH cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewDHH has good stability under different environmental conditions
DHH plays a significant role in signal transduction pathways.
DHH has good absorbability and high bioavailability.
Q&As (6)
Ask a questionThere is no conclusive evidence that DHH protein deficiency affects the development of the reproductive system, but research suggests that it may be involved in the development of the male reproductive system.
The function of DHH protein in the cardiovascular system is unknown, but studies suggest that it may be involved in the differentiation and maturation process of cardiomyocytes.
Studies have shown that DHH protein may be involved in the development of autism, but the specific mechanism is not clear.
The function of DHH protein in the nervous system is mainly to promote the differentiation and maturation of neurons, as well as the formation of synapses and the conduction of nerve signals.
DHH protein deficiency may affect mental development, but the exact extent of the effect needs further research.
Studies have shown that DHH protein may play an important role in the pathogenesis of arthritis, but its specific role needs to be further studied.
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