Recombinant Mouse Dkk3 Protein, Myc/DDK-tagged

• Cat.No.: Dkk3-2572M
• Product Overview: Purified recombinant protein of mouse full-length dickkopf WNT signaling pathway inhibitor 3 (Dkk3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 38.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Mus musculus (house mouse) ]
• Official Symbol: Dkk3
• Synonyms: DKK3; dickkopf homolog 3 (Xenopus laevis); dickkopf-related protein 3; dkk-3; mDkk-3; dickkopf-3; C87148; AW061014
• Gene ID: 50781
• mRNA Refseq: NM_015814
• Protein Refseq: NP_056629
• UniProt ID: Q9QUN9