Recombinant Mouse Dupd1 Protein, Myc/DDK-tagged

• Cat.No.: Dupd1-2677M
• Product Overview: Purified recombinant protein of mouse full-length dual specificity phosphatase and pro isomerase domain containing 1 (Dupd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 24.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dupd1 dual specificity phosphatase and pro isomerase domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Dupd1
• Synonyms: DUPD1; dual specificity phosphatase and pro isomerase domain containing 1; dual specificity phosphatase DUPD1; EG435391
• Gene ID: 435391
• mRNA Refseq: NM_001013826
• Protein Refseq: NP_001013848
• UniProt ID: Q8BK84